Title:

A REVIEW OF SECONDARY METABOLITES IN HERBAL ANTIOXIDANTS WITH NEPHROPROTECTIVE POTENTIAL

Author:

Rajiv Ranajn Kumar and Dr. Pankaj Motilal Chaudhari

Abstract:

The kidney is vulnerable to oxidative stress caused by toxicants, drugs, and metabolic diseases, which may lead to nephrotoxicity and renal dysfunction. Secondary metabolites from medicinal herbs are natural antioxidants exhibiting significant nephroprotective potential by scavenging free radicals, enhancing endogenous antioxidants, and modulating inflammatory pathways. This review summarizes key secondary metabolites, their sources, mechanisms of action, and experimental evidence supporting their nephroprotective effects. The review highlights flavonoids, phenolic acids, terpenoids, alkaloids, and their role against induced nephrotoxicity in vitro and in vivo.

Keyword:

Herbal antioxidants, secondary metabolites, nephroprotection, flavonoids